Abstract
The Aspergillus fumigatus DeltapmrA (Golgi apparatus Ca(2+)/Mn(2+) P-type ATPase) strain has osmotically suppressible basal growth defects and cationic tolerance associated with increased expression of calcineurin pathway genes. Despite increased beta-glucan and chitin content, it is hypersensitive to cell wall inhibitors but remains virulent, suggesting a role for PmrA in cation homeostasis and cell wall integrity.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoglycosides / pharmacology
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Animals
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Antifungal Agents / pharmacology
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Aspergillus fumigatus / genetics
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Aspergillus fumigatus / metabolism*
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Aspergillus fumigatus / pathogenicity*
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Calcium-Transporting ATPases / genetics*
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Calcium-Transporting ATPases / metabolism*
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Caspofungin
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Cations / metabolism*
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Cations / pharmacology
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Cell Proliferation / drug effects
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Cell Wall / drug effects
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Cell Wall / genetics
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Cell Wall / metabolism*
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Chitin / metabolism
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Drug Resistance, Fungal / genetics
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Echinocandins / pharmacology
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Egtazic Acid / pharmacology
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Fungal Proteins / genetics
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Gene Expression / drug effects
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Gene Expression / genetics
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Golgi Apparatus / enzymology*
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Homeostasis* / genetics
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Hydrogen-Ion Concentration
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Invasive Pulmonary Aspergillosis / genetics
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Invasive Pulmonary Aspergillosis / pathology
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Kaplan-Meier Estimate
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Lipopeptides
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Lung / pathology
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Male
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Mice
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Mice, Inbred Strains
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Saline Solution, Hypertonic / pharmacology
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Sorbitol / pharmacology
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Stress, Physiological / genetics
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Up-Regulation / genetics
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beta-Glucans / metabolism
Substances
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Aminoglycosides
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Antifungal Agents
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Cations
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Echinocandins
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Fungal Proteins
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Lipopeptides
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Saline Solution, Hypertonic
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beta-Glucans
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Chitin
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Sorbitol
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Egtazic Acid
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nikkomycin
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Calcium-Transporting ATPases
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Caspofungin