[Pharmacogenomics in routine medical care]

Dtsch Med Wochenschr. 2010 Jan;135(4):133-44; quiz 145-6. doi: 10.1055/s-0029-1244830. Epub 2010 Jan 25.
[Article in German]

Abstract

Pharmacogenomics investigates inherited differences in drug responses including beneficial and adverse reactions. While a considerable amount of evidence for genetic influences on drug responses has been accumulated within the last decade, predominantly in small studies, its value in routine therapy is still a matter of debate. The aim of this review is to discuss well established examples where pharmacogenomic techniques can improve routine treatment. Examples include genotyping of CYP2D6 in the context of antidepressant therapy, analysis of TPMT variants for the prediction of mercaptopurine-induced bone marrow depression, VKORC1 and CYP2C9 analyses for a better control of anticoagulant administration and the SLCO1B1 variant in the context of statin-induced myopathies.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Alleles
  • Anticholesteremic Agents / pharmacokinetics
  • Anticholesteremic Agents / toxicity
  • Anticoagulants / pharmacokinetics
  • Anticoagulants / toxicity
  • Antitussive Agents / pharmacokinetics
  • Antitussive Agents / toxicity
  • Aryl Hydrocarbon Hydroxylases / genetics
  • Biological Availability
  • Biotransformation / genetics
  • Codeine / pharmacokinetics
  • Codeine / toxicity
  • Cytochrome P-450 CYP2C9
  • Cytochrome P-450 CYP2D6 / genetics
  • Cytochrome P-450 CYP3A / genetics
  • Cytochrome P-450 CYP3A Inhibitors
  • Drug Therapy, Combination
  • Female
  • Genotype
  • Humans
  • Inactivation, Metabolic / genetics
  • Liver-Specific Organic Anion Transporter 1
  • Male
  • Metabolic Clearance Rate / genetics
  • Methyltransferases / deficiency
  • Methyltransferases / genetics
  • Middle Aged
  • Narcotics / pharmacokinetics
  • Narcotics / toxicity
  • Organic Anion Transporters / genetics
  • Pharmacogenetics*
  • Phenotype
  • Phenprocoumon / pharmacokinetics
  • Phenprocoumon / toxicity
  • Point Mutation / genetics
  • Polymorphism, Genetic / genetics
  • Precision Medicine*
  • Simvastatin / pharmacokinetics
  • Simvastatin / toxicity
  • Warfarin / pharmacokinetics
  • Warfarin / toxicity

Substances

  • Anticholesteremic Agents
  • Anticoagulants
  • Antitussive Agents
  • Cytochrome P-450 CYP3A Inhibitors
  • Liver-Specific Organic Anion Transporter 1
  • Narcotics
  • Organic Anion Transporters
  • SLCO1B1 protein, human
  • Warfarin
  • Simvastatin
  • CYP2C9 protein, human
  • Cytochrome P-450 CYP2C9
  • Aryl Hydrocarbon Hydroxylases
  • Cytochrome P-450 CYP2D6
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human
  • Methyltransferases
  • thiopurine methyltransferase
  • Phenprocoumon
  • Codeine