Deletion variant of alpha2b-adrenergic receptor gene moderates the effect of COMT val(158)met polymorphism on episodic memory performance

Ayana A Gibbs; Kris H Naudts; Ruben T Azevedo; Anthony S David

doi:10.1016/j.euroneuro.2009.12.007

Deletion variant of alpha2b-adrenergic receptor gene moderates the effect of COMT val(158)met polymorphism on episodic memory performance

Eur Neuropsychopharmacol. 2010 Apr;20(4):272-5. doi: 10.1016/j.euroneuro.2009.12.007. Epub 2010 Jan 27.

Authors

Ayana A Gibbs¹, Kris H Naudts, Ruben T Azevedo, Anthony S David

Affiliation

¹ Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King's College London, United Kingdom. [email protected]

PMID: 20110158
DOI: 10.1016/j.euroneuro.2009.12.007

Abstract

The COMT val(158) variant has been associated with impaired cognitive function compared to the met(158) variant yet gene-gene interactions are not well described. In this study we demonstrate an interaction between this COMT polymorphism and a deletion variant of ADRA2B, the gene encoding the alpha2b-adrenergic receptor on episodic memory performance. Specifically, carriage of the ADRA2B deletion abolished the relative memory impairment in homozygous COMT val(158) carriers compared to met(158) carriers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Catechol O-Methyltransferase / genetics
Catechol O-Methyltransferase / physiology*
Gene Deletion*
Genotype
Humans
Male
Mental Recall / physiology*
Polymorphism, Genetic / physiology
Receptors, Adrenergic, alpha-2 / genetics
Receptors, Adrenergic, alpha-2 / physiology*

Substances

ADRA2B protein, human
Receptors, Adrenergic, alpha-2
Catechol O-Methyltransferase