Abstract
Recent studies have revealed a prominent role of mitochondrial dysfunction in the development of one of the most common neurodegenerative disorders, Parkinson's disease. The ubiquitin ligase Parkin and the protein kinase PINK1, whose mutations are associated with Parkinson's disease, function in a pathway that links ubiquitylation with selective autophagy of damaged mitochondria.
MeSH terms
-
Animals
-
Autophagy / genetics
-
Autophagy / physiology
-
Humans
-
Mitochondria / metabolism*
-
Parkinson Disease / enzymology
-
Parkinson Disease / genetics
-
Parkinson Disease / metabolism*
-
Protein Kinases / genetics
-
Protein Kinases / metabolism
-
Signal Transduction / genetics
-
Signal Transduction / physiology
-
Ubiquitin-Protein Ligases / genetics
-
Ubiquitin-Protein Ligases / metabolism
Substances
-
Ubiquitin-Protein Ligases
-
parkin protein
-
Protein Kinases
-
PTEN-induced putative kinase