Actinomycin D decreases protein kinase C content and induces neuritogenesis in neuroblastoma cells

M D Miñana; V Felipo; S Grisolía

doi:10.1016/0014-5793(91)80302-j

Actinomycin D decreases protein kinase C content and induces neuritogenesis in neuroblastoma cells

FEBS Lett. 1991 Mar 25;280(2):245-6. doi: 10.1016/0014-5793(91)80302-j.

Authors

M D Miñana¹, V Felipo, S Grisolía

Affiliation

¹ Instituto de Investigaciones Citológicas de la Caja de Ahorros de Valencia, Centro Asociado del CSIC, Valencia, Spain.

PMID: 2013318
DOI: 10.1016/0014-5793(91)80302-j

Abstract

We have previously reported that inhibition of protein kinase C induces differentiation of neuroblastoma cells in culture. It is shown now that actinomycin D, a well known inhibitor of DNA synthesis, reduces selectively the content of protein kinase C and induces neuritogenesis in Neuro 2a cells in culture.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Differentiation*
DNA / biosynthesis
Dactinomycin / pharmacology*
Mice
Neuroblastoma / drug therapy
Neuroblastoma / genetics
Neuroblastoma / metabolism*
Neuroblastoma / pathology
Protein Kinase C / metabolism*
Tumor Cells, Cultured

Substances

Dactinomycin
DNA
Protein Kinase C