Distribution of HPV types associated with cervical cancers in Scotland and implications for the impact of HPV vaccines

Br J Cancer. 2010 Mar 2;102(5):930-2. doi: 10.1038/sj.bjc.6605556. Epub 2010 Feb 9.

Abstract

Background/methods: This study evaluated human papillomavirus (HPV) type prevalence in 370 Scottish invasive cervical cancers (ICCs) using HPV genotyping and HPV mRNA detection.

Results: HPV 16 and/or 18 was detected in 72% of cancers overall and in 82% of HPV-positive cancers. HPV 45 and 16 were the most frequently transcribed types.

Conclusion: A significant reduction in ICC in Scotland should be achieved through the HPV immunisation programme.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / epidemiology
  • Adenocarcinoma / prevention & control*
  • Adenocarcinoma / virology
  • Adult
  • Aged
  • Carcinoma, Squamous Cell / epidemiology
  • Carcinoma, Squamous Cell / prevention & control*
  • Carcinoma, Squamous Cell / virology
  • Female
  • Humans
  • Middle Aged
  • Papillomaviridae / classification
  • Papillomaviridae / genetics*
  • Papillomavirus Infections / epidemiology
  • Papillomavirus Infections / prevention & control*
  • Papillomavirus Infections / virology
  • Papillomavirus Vaccines / therapeutic use*
  • Prognosis
  • Scotland / epidemiology
  • Survival Rate
  • Uterine Cervical Neoplasms / epidemiology
  • Uterine Cervical Neoplasms / prevention & control*
  • Uterine Cervical Neoplasms / virology

Substances

  • Papillomavirus Vaccines