Abstract
Two distinct "click" chemistry labeling approaches were investigated with dipyridylamine alkyne derivatives and M(CO)(3)(+) (M = Re, (99m)Tc). The triazole ring was found uncoordinated and was incorporated into the preparation of a crossover androgen receptor targeting inhibitor for prostate cancer.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Crystallography, X-Ray
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Flutamide / chemistry*
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Humans
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Isotope Labeling
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Male
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Molecular Conformation
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Prostatic Neoplasms / diagnostic imaging*
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Radionuclide Imaging
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Radiopharmaceuticals / chemistry*
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Receptors, Androgen / analysis*
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Receptors, Androgen / chemistry
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Rhenium / chemistry*
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Technetium / chemistry*
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Triazoles / chemistry
Substances
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Radiopharmaceuticals
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Receptors, Androgen
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Triazoles
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Rhenium
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Technetium
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Flutamide