Abstract
We describe a unique case of fulminant infectious mononucleosis and recurrent Epstein-Barr virus reactivation presenting in an adolescent. Detailed assays of Epstein-Barr virus-specific T cell immunity revealed defects in the patient's T cell receptor signalling pathway characterized by a lack of interleukin-2 and CD25 expression, which may have contributed to her clinical course. Allogeneic stem cell transplantation reversed the clinical and laboratory phenotype.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Child
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Herpesvirus 4, Human / immunology*
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Herpesvirus 4, Human / isolation & purification*
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Humans
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Infectious Mononucleosis / diagnosis*
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Infectious Mononucleosis / immunology*
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Infectious Mononucleosis / therapy
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Interleukin-2 / deficiency
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Interleukin-2 Receptor alpha Subunit / deficiency
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Receptors, Antigen, T-Cell / deficiency
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Recurrence
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Stem Cell Transplantation
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T-Lymphocytes / immunology
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Virus Activation*
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Young Adult
Substances
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Interleukin-2
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Interleukin-2 Receptor alpha Subunit
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Receptors, Antigen, T-Cell