A Robust QTL Mapping Procedure

J Stat Plan Inference. 2009 Mar 1;139(3):978-989. doi: 10.1016/j.jspi.2008.06.009.

Abstract

In quantitative-trait linkage studies using experimental crosses, the conventional normal location-shift model or other parameterizations may be unnecessarily restrictive. We generalize the mapping problem to a genuine nonparametric setup and provide a robust estimation procedure for the situation where the underlying phenotype distributions are completely unspecified. Classical Wilcoxon-Mann-Whitney statistics are employed for point and interval estimation of QTL positions and effects.