Chronic urticaria of neonatal onset: a potential sign of autoinflammation

J Paediatr Child Health. 2010 Oct;46(10):608-10. doi: 10.1111/j.1440-1754.2009.01688.x.

Abstract

We present a 6 year old boy with chronic urticaria of neonatal onset associated in childhood with features of neurological and joint inflammation. Genetic analysis confirmed the diagnosis of neonatal onset multi-inflammatory disorder (NOMID). Daily subcutaneous anti-IL-1 receptor antagonist therapy resulted in a dramatic and sustained amelioration of systemic inflammation. NOMID must be considered in any child with chronic urticaria of neonatal/infantile onset, particularly if associated with joint and/or neurological inflammation.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Australia
  • Autoimmune Diseases / diagnosis*
  • Child, Preschool
  • Chronic Disease
  • Humans
  • Male
  • Urticaria / diagnosis
  • Urticaria / physiopathology*