New aspects in vascular gene therapy

Henna Karvinen; Seppo Ylä-Herttuala

doi:10.1016/j.coph.2010.01.004

New aspects in vascular gene therapy

Curr Opin Pharmacol. 2010 Apr;10(2):208-11. doi: 10.1016/j.coph.2010.01.004. Epub 2010 Feb 15.

Authors

Henna Karvinen¹, Seppo Ylä-Herttuala

Affiliation

¹ Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Finland.

PMID: 20163988
DOI: 10.1016/j.coph.2010.01.004

Abstract

Advances in clinical gene therapy have been modest although significant progress has been made during the past few years. New viruses have been introduced and new results have been collected from preclinical and clinical studies. This review will focus on cardiovascular and especially proangiogenic gene therapy. Recent results from preclinical developments and clinical trials will be discussed.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cardiovascular Diseases / therapy*
Clinical Trials as Topic
Gene Transfer Techniques / adverse effects
Genetic Therapy / adverse effects
Genetic Therapy / methods*
Genetic Vectors / adverse effects
Genetic Vectors / therapeutic use
Humans
Neovascularization, Physiologic / genetics*
Viruses