Abstract
A bis (thiosemicarbazonato) complex radiolabeled with positron emitting Cu-64 can be used for a new and alternative method for the non-invasive diagnosis of Alzheimer's disease using positron emission tomography (PET). Most imaging agents being investigated for the diagnosis of Alzheimer's disease target amyloid-beta plaque burden but our new approach highlights altered copper homeostasis. This approach has the potential to offer complementary information to other diagnostic procedures that elucidate plaque burden.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alzheimer Disease / diagnostic imaging*
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Amyloid beta-Protein Precursor / genetics
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Animals
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Brain / diagnostic imaging
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Brain Mapping
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Copper Radioisotopes* / chemistry
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Disease Models, Animal
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Humans
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Mice
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Mice, Transgenic
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Positron-Emission Tomography / methods*
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Presenilin-1 / genetics
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Radiopharmaceuticals* / chemistry
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Tissue Distribution
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alpha-Synuclein / metabolism
Substances
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Amyloid beta-Protein Precursor
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Copper Radioisotopes
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PSEN1 protein, human
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Presenilin-1
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Radiopharmaceuticals
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alpha-Synuclein