1-(carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists

J Med Chem. 1991 Apr;34(4):1514-7. doi: 10.1021/jm00108a043.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Acrylates / chemical synthesis*
  • Acrylates / chemistry
  • Acrylates / pharmacology
  • Angiotensin II / antagonists & inhibitors*
  • Angiotensin II / metabolism
  • Angiotensin Receptor Antagonists
  • Animals
  • Aorta / drug effects
  • Aorta / physiology
  • Blood Pressure / drug effects*
  • Dogs
  • Imidazoles / chemical synthesis*
  • Imidazoles / chemistry
  • Imidazoles / pharmacology
  • In Vitro Techniques
  • Indicators and Reagents
  • Kidney / drug effects
  • Kidney / physiology
  • Molecular Conformation
  • Molecular Structure
  • Muscle, Smooth, Vascular / drug effects
  • Muscle, Smooth, Vascular / physiology
  • Rabbits
  • Rats
  • Receptors, Angiotensin / drug effects*
  • Receptors, Angiotensin / metabolism
  • Structure-Activity Relationship
  • Thiophenes*
  • Vasoconstriction / drug effects*

Substances

  • Acrylates
  • Angiotensin Receptor Antagonists
  • Imidazoles
  • Indicators and Reagents
  • Receptors, Angiotensin
  • Thiophenes
  • Angiotensin II
  • eprosartan