Identification of a common autoantigenic epitope of protein disulfide isomerase, golgin-160 and voltage-gated potassium channel in type 1 diabetes

Alessandra Fierabracci; Francesca Saura

doi:10.1016/j.diabres.2010.01.018

Identification of a common autoantigenic epitope of protein disulfide isomerase, golgin-160 and voltage-gated potassium channel in type 1 diabetes

Diabetes Res Clin Pract. 2010 May;88(2):e14-6. doi: 10.1016/j.diabres.2010.01.018. Epub 2010 Feb 18.

Authors

Alessandra Fierabracci¹, Francesca Saura

Affiliation

¹ Autoimmunity and Organ Regeneration Laboratory, Children's Hospital Bambino Gesù, Research Institute (IRCCS), Piazza S. Onofrio 4, 00165 Rome, Italy. [email protected]

PMID: 20170975
DOI: 10.1016/j.diabres.2010.01.018

Abstract

A common epitope of proteins golgin-160, voltage-gated potassium channel and disulfide isomerase was identified by screening with autoantibodies of a type 1 diabetic (T1D) patient a lambdaUni-Zap cDNA library from human diabetic islets. The significance of the identified autoantigens to the disease pathogenesis remains to be elucidated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Autoantibodies
Autoantigens / immunology*
Diabetes Mellitus, Type 1 / immunology*
Epitopes*
Gene Library
Golgi Matrix Proteins
Humans
Islets of Langerhans / immunology
Membrane Proteins / immunology*
Potassium Channels, Voltage-Gated / immunology*
Protein Disulfide-Isomerases / immunology*

Substances

Autoantibodies
Autoantigens
Epitopes
GOLGA3 protein, human
Golgi Matrix Proteins
Membrane Proteins
Potassium Channels, Voltage-Gated
Protein Disulfide-Isomerases