IMRT-based optimization approaches for volumetric modulated single arc radiotherapy planning

Wouter Crijns; Tom Budiharto; Gilles Defraene; Jan Verstraete; Tom Depuydt; Karin Haustermans; Frank Van den Heuvel

doi:10.1016/j.radonc.2010.01.012

IMRT-based optimization approaches for volumetric modulated single arc radiotherapy planning

Radiother Oncol. 2010 May;95(2):149-52. doi: 10.1016/j.radonc.2010.01.012. Epub 2010 Feb 18.

Authors

Wouter Crijns¹, Tom Budiharto, Gilles Defraene, Jan Verstraete, Tom Depuydt, Karin Haustermans, Frank Van den Heuvel

Affiliation

¹ Department of Radiotherapy, University Hospital Leuven, Leuven, Belgium. [email protected]

PMID: 20171750
DOI: 10.1016/j.radonc.2010.01.012

Abstract

This paper reports on an evaluation of 5 RapidArc optimization approaches vs IMRT. This study includes 11 patients with adenocarcinoma of the prostate. Rectal Normal Tissue Complication Probability is used as a constraint in a dose escalation. RapidArc rectal NTCP's are lower than those of IMRT (p = 0.007). This allows a mean dose escalation of 2.1 Gy([0.7 Gy,3.5 Gy]).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma / radiotherapy*
Humans
Male
Prostatic Neoplasms / radiotherapy*
Radiation Dosage
Radiotherapy Planning, Computer-Assisted / instrumentation*
Radiotherapy Planning, Computer-Assisted / methods*
Radiotherapy, Intensity-Modulated / methods*