Abstract
The in vitro activity of TR-700 (torezolid) was evaluated against a collection of 660 staphylococcal blood isolates. TR-700 showed excellent activity against all the staphylococci tested. The MIC(50) and MIC(90) values of TR-700, linezolid, daptomycin, and vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) isolates were 0.25 and 0.5, 2 and 4, 0.5 and 0.5, and 1 and 2 microg/ml, respectively. TR-700 demonstrated greater in vitro potency than linezolid against staphylococci, including linezolid-resistant and vancomycin-nonsusceptible strains, and was 32-fold more active than linezolid against the seven cfr-positive MRSA strains tested.
MeSH terms
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Acetamides / pharmacology
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Anti-Bacterial Agents / pharmacology*
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Daptomycin / pharmacology
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Drug Resistance, Bacterial / drug effects
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In Vitro Techniques
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Linezolid
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Methicillin-Resistant Staphylococcus aureus / isolation & purification*
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Microbial Sensitivity Tests
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Oxazolidinones / pharmacology*
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Sepsis / drug therapy
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Sepsis / microbiology
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Spain
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology
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Tetrazoles / pharmacology*
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Vancomycin / pharmacology
Substances
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Acetamides
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Anti-Bacterial Agents
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Oxazolidinones
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Tetrazoles
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Vancomycin
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tedizolid
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Linezolid
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Daptomycin