Imipramine treatment of methadone maintenance patients with affective disorder and illicit drug use

E V Nunes; F M Quitkin; R Brady; J W Stewart

doi:10.1176/ajp.148.5.667

Imipramine treatment of methadone maintenance patients with affective disorder and illicit drug use

Am J Psychiatry. 1991 May;148(5):667-9. doi: 10.1176/ajp.148.5.667.

Authors

E V Nunes¹, F M Quitkin, R Brady, J W Stewart

Affiliation

¹ Depression Evaluation Service, New York State Psychiatric Institute, NY 10032.

PMID: 2018172
DOI: 10.1176/ajp.148.5.667

Abstract

Of 17 consecutive patients receiving methadone maintenance treatment who had primary or chronic depression, nine (53%) improved in both mood and drug abuse after imipramine treatment. This finding suggests a potential for helping such dual-diagnosis patients reduce drug abuse and associated risk for HIV. Further controlled trials are warranted.

MeSH terms

Adult
Cocaine
Depressive Disorder / drug therapy*
Drug Therapy, Combination
Female
Heroin Dependence / drug therapy
Heroin Dependence / rehabilitation
Humans
Imipramine / therapeutic use*
Male
Methadone / therapeutic use*
Pilot Projects
Substance Abuse, Intravenous / drug therapy
Substance Abuse, Intravenous / rehabilitation
Substance-Related Disorders / drug therapy*
Substance-Related Disorders / rehabilitation

Substances

Cocaine
Imipramine
Methadone