Abstract
Chemical investigation of Trogopterus feces has led to the isolation of four new long-chain aliphatics, including two new fatty alcohols, 8,15-nonacosanediol (1) and 6,13-nonacosanediol (2), one new fatty acid ester, dihexyl 7,7'-oxydiheptanoate (3), and one new ceramide, (2R)-2-hydroxy-N-[(2S,3S,4R,11E)-1,3,4-trihydroxydocos-11-en-2-yl]heneicosanamide (4). Their structures were elucidated by means of chemical and extensive spectroscopic analysis. Compound 3 exhibited moderate activity of antithrombin in vitro.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anticoagulants / chemistry
-
Anticoagulants / isolation & purification*
-
Anticoagulants / pharmacology
-
Ceramides / chemistry
-
Fatty Alcohols / chemistry
-
Fatty Alcohols / isolation & purification*
-
Fatty Alcohols / pharmacology
-
Feces / chemistry
-
Fibrinolytic Agents / chemistry
-
Fibrinolytic Agents / isolation & purification*
-
Fibrinolytic Agents / pharmacology
-
Molecular Structure
-
Sciuridae*
-
Stereoisomerism
Substances
-
Anticoagulants
-
Ceramides
-
Fatty Alcohols
-
Fibrinolytic Agents