Sensitivity analysis of informatively coarsened data using pattern mixture models

J Biopharm Stat. 2009 Nov;19(6):1018-38. doi: 10.1080/10543400903242779.

Abstract

We use the framework of coarsened data to motivate performing sensitivity analysis in the presence of incomplete data. To perform the sensitivity analysis, we specify pattern-mixture models to allow departures from the assumption of coarsening at random, a generalization of missing at random and independent censoring. We apply the concept of coarsening to address potential bias from missing data and interval-censored data in a randomized controlled trial of an herbal treatment for acute hepatitis. Computer code using SAS PROC NLMIXED for fitting the models is provided.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Alanine Transaminase / blood
  • Bilirubin / blood
  • Computer Simulation
  • Data Interpretation, Statistical*
  • Follow-Up Studies
  • Hepatitis / drug therapy
  • Humans
  • Models, Statistical*
  • Randomized Controlled Trials as Topic

Substances

  • Alanine Transaminase
  • Bilirubin