Abstract
The strategy of induction chemotherapy prior to planned definitive local therapy for head and neck squamous cell carcinoma has been studied for over 30 years, and appears to have a role in select clinical situations. Here we review landmark studies regarding induction chemotherapy, both in the pre-taxane era and in the current taxane era, and we address some of the unresolved questions regarding the role of induction chemotherapy in head and neck cancer.
MeSH terms
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / therapeutic use*
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Bridged-Ring Compounds / therapeutic use
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Carcinoma, Squamous Cell / pathology
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Carcinoma, Squamous Cell / therapy*
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Chemotherapy, Adjuvant
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Head and Neck Neoplasms / pathology
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Head and Neck Neoplasms / therapy*
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Humans
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Neoadjuvant Therapy
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Patient Selection
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Taxoids / therapeutic use
Substances
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Antineoplastic Agents
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Bridged-Ring Compounds
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Taxoids
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taxane