High selenium may be a risk factor of adolescent idiopathic scoliosis

Zongde Yang; Yang Xie; Jiayu Chen; Diqing Zhang; Changwei Yang; Ming Li

doi:10.1016/j.mehy.2010.02.006

High selenium may be a risk factor of adolescent idiopathic scoliosis

Med Hypotheses. 2010 Jul;75(1):126-7. doi: 10.1016/j.mehy.2010.02.006. Epub 2010 Feb 26.

Authors

Zongde Yang¹, Yang Xie, Jiayu Chen, Diqing Zhang, Changwei Yang, Ming Li

Affiliation

¹ Scoliosis Research Center, Orthopedic Department, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.

PMID: 20189316
DOI: 10.1016/j.mehy.2010.02.006

Abstract

The pathogenesis of adolescent idiopathic scoliosis (AIS) remains little understood. Previous work has shown that guppy fish is an ideal animal model of idiopathic scoliosis which has similar epidemiological and morphological characteristic with AIS. However, some research speculated that the high-selenium environment could also induce idiopathic-type scoliosis of fish. We believe that the high-selenium related deformity of spine and guppy curveback syndrome may have the same pathogenesis. And high selenium may be a risk factor of AIS.

MeSH terms

Adolescent
Humans
Risk Factors
Scoliosis / chemically induced*
Selenium / administration & dosage
Selenium / toxicity*

Substances

Selenium