For T cell receptors, some breakups might not last forever

Christopher C Govern; Arup K Chakraborty

doi:10.1016/j.immuni.2010.02.005

For T cell receptors, some breakups might not last forever

Immunity. 2010 Feb 26;32(2):141-2. doi: 10.1016/j.immuni.2010.02.005.

Authors

Christopher C Govern¹, Arup K Chakraborty

Affiliation

¹ Department of Chemical Engineering, Massachusetts Institute of Technology, 770 Massachusetts Avenue, Cambridge, MA 02139, USA.

PMID: 20189475
DOI: 10.1016/j.immuni.2010.02.005

Abstract

Does the affinity or half-life of peptide-MHC-T cell receptor (TCR) interactions determine T cell activation? In this issue of Immunity, Aleksic et al. (2010) propose a role for the on rate through multiple rebindings to the same TCR.

Publication types

Comment

MeSH terms

Cytotoxicity, Immunologic
HLA Antigens / immunology
HLA Antigens / metabolism
Humans
Lymphocyte Activation*
Models, Immunological
Peptide Fragments / immunology
Peptide Fragments / metabolism
Protein Binding
Receptors, Antigen, T-Cell / immunology
Receptors, Antigen, T-Cell / metabolism*
Signal Transduction / immunology
Structure-Activity Relationship
T-Lymphocytes / immunology
T-Lymphocytes / metabolism*
T-Lymphocytes / pathology
Time Factors

Substances

HLA Antigens
Peptide Fragments
Receptors, Antigen, T-Cell