Objective: To investigate whether there was a correlation between lipid level, hemorheology and the obstructive sleep apnea hypopnea syndrome.
Methods: Two hundred and thirty-one subjects in our sleep respiratory disease center between 2006 and 2009 were included. Eighty nine were obese OSAHS subjects, 62 were non-obese OSAHS subjects, 40 were obese subjects without OSAHS (obese group) and 40 were non-obese subjects without OSAHS (control group). We examined and compared the lipid profile and hemorheology in all subjects.
Results: In obese OSAHS group, the levels of triglyceride (TG) [(2.74 +/- 2.02) mmol/L], cholesterol (TC) [(5.14 +/- 0.96) mmol/L] were higher and HDL [(1.13 +/- 0.36) mmol/L], apoA-I [(1.20 +/- 0.20) mmol/L] were lower, compared to the non-obese OSAHS group (F = 7.77, 7.99, all P < 0.01). The level of the whole blood viscosity in obese OSAHS group was significantly higher than that in non-obese OSAHS group (F = 8.81-11.99, P < 0.05). There was no significant difference in blood lipid levels among the 2 study groups:non-obese OSAHS and control group, obese OSAHS and obese group (F = 6.42 - 11.99, P > 005). The levels of the whole blood viscosity and HCT were significantly higher in non-obese OSAHS group than in control group (F = 0.41 - 2.23, P < 0.05); obese OSAHS group were higher than obese group (F = 0.12 - 2.10, P < 0.05). No significant difference in blood lipid levels was noted among the 4 non-obese groups with different disease severity; similar result was also observed among obese OSAHS groups.
Conclusions: Obesity is responsible for dyslipidemia in OSAHS. OSAHS has no significant correlation with lipid abnormalities, but it significantly correlates with hemorheology disorder.