Abstract
Steroidogenic factor-1 (SF-1/Ad4-binding protein; NR5A1) is an essential regulator of tissue-specific gene expression in steroidogenic cells and of adrenogonadal development. Here, I discuss recent data in the literature showing the implication of SF-1 and the importance of its dosage not only during development but also for adrenal cortex tumorigenesis in humans and mice.
MeSH terms
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Adrenal Cortex Neoplasms / genetics
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Adrenal Cortex Neoplasms / metabolism*
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Adrenal Glands / growth & development*
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Adult
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Animals
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Enhancer Elements, Genetic
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Female
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Homeodomain Proteins / genetics
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Homeodomain Proteins / physiology
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Humans
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Male
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Mice
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Promoter Regions, Genetic
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Steroidogenic Factor 1 / genetics
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Steroidogenic Factor 1 / physiology*
Substances
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Homeodomain Proteins
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Steroidogenic Factor 1