Two new chalcones from leaves of Morus alba L

Yan Yang; Ting Zhang; Lei Xiao; Lixin Yang; Ruoyun Chen

doi:10.1016/j.fitote.2010.03.005

Two new chalcones from leaves of Morus alba L

Fitoterapia. 2010 Sep;81(6):614-6. doi: 10.1016/j.fitote.2010.03.005. Epub 2010 Mar 6.

Authors

Yan Yang¹, Ting Zhang, Lei Xiao, Lixin Yang, Ruoyun Chen

Affiliation

¹ Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

PMID: 20211228
DOI: 10.1016/j.fitote.2010.03.005

Abstract

Two new chalcone derivatives named morachalcones B and C (1 and 2) were isolated from the leaves of Morus alba L. Their structures were elucidated by spectroscopic analysis. Morachalcones B (1) and C (2) represent two examples of chalcones having unusual furan rings which are formed by cyclization between C-alpha-OH and C-2-OH. Compounds 1 and 2 displayed only moderate cytotoxic activity against HCT-8 and BGC823 human cancer cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Cell Line, Tumor
Chalcones / chemistry
Chalcones / isolation & purification*
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Morus / chemistry*
Plant Leaves / chemistry
Plants, Medicinal / chemistry

Substances

Antineoplastic Agents, Phytogenic
Chalcones
morachalcone B
morachalcone C