Photoinduced DNA damage efficiency and cytotoxicity of novel viologen linked pyrene conjugates

Mahesh Hariharan; Suneesh C Karunakaran; Danaboyina Ramaiah; Ina Schulz; Bernd Epe

doi:10.1039/b924943e

Photoinduced DNA damage efficiency and cytotoxicity of novel viologen linked pyrene conjugates

Chem Commun (Camb). 2010 Mar 28;46(12):2064-6. doi: 10.1039/b924943e. Epub 2010 Feb 18.

Authors

Mahesh Hariharan¹, Suneesh C Karunakaran, Danaboyina Ramaiah, Ina Schulz, Bernd Epe

Affiliation

¹ Photosciences & Photonics, National Institute for Interdisciplinary Science & Technology, CSIR, Trivandrum 695 019, India.

PMID: 20221493
DOI: 10.1039/b924943e

Abstract

Novel viologen linked pyrene conjugates permeate cells efficiently and exhibit spacer length dependent DNA damage and cytotoxicity upon photoexcitation.

MeSH terms

Animals
DNA Damage*
Mice
Photochemistry*
Pyrenes / chemistry*
Ultraviolet Rays
Viologens / chemistry*

Substances

Pyrenes
Viologens
pyrene