Patterned multiplex pathogen DNA detection by Au particle-on-wire SERS sensor

Nano Lett. 2010 Apr 14;10(4):1189-93. doi: 10.1021/nl1000086.

Abstract

A Au particle-on-wire system that can be used as a specific, sensitive, and multiplex DNA sensor is developed. A pattern formed by multiple Au nanowire sensors provides positional address and identification for each sensor. By using this system, multiplex sensing of target DNAs was possible in a quantitative manner with a detection limit of 10 pM. Target DNAs from reference bacteria and clinical isolates were successfully identified by this sensor system, enabling diagnostics for infectious diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques / instrumentation
  • Biosensing Techniques / methods*
  • DNA, Bacterial / analysis*
  • Gold / chemistry*
  • Metal Nanoparticles / chemistry*
  • Nanotechnology / methods*
  • Nanowires / chemistry*
  • Particle Size
  • Sensitivity and Specificity
  • Surface Properties

Substances

  • DNA, Bacterial
  • Gold