Comparison of drug permeabilities and BCS classification: three lipid-component PAMPA system method versus Caco-2 monolayers

AAPS J. 2010 Jun;12(2):238-41. doi: 10.1208/s12248-010-9176-2. Epub 2010 Mar 12.
No abstract available

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic beta-Antagonists / metabolism
  • Animals
  • Caco-2 Cells
  • Cell Line
  • Cell Membrane Permeability / drug effects
  • Dogs
  • Humans
  • Membranes, Artificial*
  • Metoprolol / metabolism
  • Pharmaceutical Preparations / classification*
  • Pharmaceutical Preparations / metabolism*
  • Predictive Value of Tests
  • Reference Standards

Substances

  • Adrenergic beta-Antagonists
  • Membranes, Artificial
  • Pharmaceutical Preparations
  • Metoprolol