N,N'-methylenediimidazolium salts: from self-assembly to an efficient DNAse protection system

Chemistry. 2010 Apr 19;16(15):4686-92. doi: 10.1002/chem.200902794. Epub 2010 Mar 12.

Abstract

We have developed N,N'-dialkylmethylenediimidazolium salts ([C(n)C(n)DIM][X]2) that self-organize into multilayered cationic vesicles and can interact with DNA. These preorganized systems form complexes with linear DNA and protect it from DNase I cleavage.

Keywords: DNA interactions; diimidazolium salts; enzymes; self-assembly; vesicles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cations
  • DNA / metabolism*
  • Deoxyribonuclease I / metabolism*
  • Hydrogen Bonding
  • Imidazoles / chemical synthesis*
  • Imidazoles / chemistry
  • Models, Chemical*
  • Molecular Structure
  • Plasmids / chemistry
  • Salts / chemical synthesis
  • Salts / chemistry

Substances

  • Cations
  • Imidazoles
  • Salts
  • DNA
  • Deoxyribonuclease I