Abstract
Lipoproteins are a largely uncharacterized class of proteins in bacteria. In this study, metabolic labeling of bacteria with fatty acid chemical reporters allowed rapid profiling of lipid-modified proteins. We identified many candidate lipoproteins in Escherichia coli and detected a novel modification on YjgF. This chemical approach should facilitate future characterization of lipoproteins.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemistry*
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Escherichia coli / chemistry
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Escherichia coli / metabolism
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Escherichia coli Proteins / chemistry*
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Escherichia coli Proteins / metabolism
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Fatty Acids / chemistry*
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Lipoproteins / chemistry*
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Lipoproteins / metabolism
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Molecular Structure
Substances
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Alkynes
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Escherichia coli Proteins
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Fatty Acids
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Lipoproteins