Locked nucleic acids: promising nucleic acid analogs for therapeutic applications

Rakesh N Veedu; Jesper Wengel

doi:10.1002/cbdv.200900343

Locked nucleic acids: promising nucleic acid analogs for therapeutic applications

Chem Biodivers. 2010 Mar;7(3):536-42. doi: 10.1002/cbdv.200900343.

Authors

Rakesh N Veedu¹, Jesper Wengel

Affiliation

¹ Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M. [email protected]

PMID: 20232325
DOI: 10.1002/cbdv.200900343

Abstract

Locked Nucleic Acid (LNA) is a unique nucleic-acid modification possessing very high binding affinity and excellent specificity toward complementary RNA or DNA oligonucleotides. The remarkable properties exhibited by LNA oligonucleotides have been employed in different nucleic acid-based therapeutic strategies both in vitro and in vivo. Herein, we highlight the applications of LNA nucleotides for controlling gene expression.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aptamers, Nucleotide / chemistry
DNA / chemistry
DNA, Catalytic / chemistry
DNA, Catalytic / metabolism
MicroRNAs / chemistry
MicroRNAs / metabolism
Oligonucleotides / chemistry*
Oligonucleotides / therapeutic use
Oligonucleotides, Antisense / chemistry
RNA, Complementary / chemistry
RNA, Small Interfering / chemistry
RNA, Small Interfering / metabolism

Substances

Aptamers, Nucleotide
DNA, Catalytic
MicroRNAs
Oligonucleotides
Oligonucleotides, Antisense
RNA, Complementary
RNA, Small Interfering
locked nucleic acid
DNA