Abstract
A novel family of Burkholderiales bacteria was identified in ileal biopsy specimens from children presenting with symptoms of inflammatory bowel disease. A molecular subtyping approach based on sequencing of a variable region of the bacteria's 23S rRNA genes identified three variants. Pilot analysis identified one variant to be significantly associated with perianal Crohn's disease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Biopsy
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Burkholderia / classification*
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Burkholderia / genetics*
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Burkholderia / isolation & purification
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Child
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Child, Preschool
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Cluster Analysis
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Crohn Disease / microbiology*
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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DNA, Ribosomal / chemistry
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DNA, Ribosomal / genetics
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Humans
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Ileum / microbiology*
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Molecular Sequence Data
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Phylogeny
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RNA, Ribosomal, 23S / genetics
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Sequence Analysis, DNA
Substances
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DNA, Bacterial
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DNA, Ribosomal
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RNA, Ribosomal, 23S
Associated data
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GENBANK/GU189522
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GENBANK/GU189523
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GENBANK/GU189524
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GENBANK/GU189525
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GENBANK/GU189526
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GENBANK/GU189527
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GENBANK/GU189528
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GENBANK/GU189529
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GENBANK/GU189530
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GENBANK/GU189531