The nucleotide sequence of a CpG island demonstrates the presence of the first exon of the gene encoding the human lysosomal membrane protein lamp2 and assigns the gene to Xq24

M Manoni; C Tribioli; B Lazzari; G DeBellis; C Patrosso; R Pergolizzi; M Pellegrini; E Maestrini; S Rivella; P Vezzoni

doi:10.1016/0888-7543(91)90424-d

The nucleotide sequence of a CpG island demonstrates the presence of the first exon of the gene encoding the human lysosomal membrane protein lamp2 and assigns the gene to Xq24

Genomics. 1991 Mar;9(3):551-4. doi: 10.1016/0888-7543(91)90424-d.

Authors

M Manoni¹, C Tribioli, B Lazzari, G DeBellis, C Patrosso, R Pergolizzi, M Pellegrini, E Maestrini, S Rivella, P Vezzoni, et al.

Affiliation

¹ Istituto di Tecnologie Biomediche Avanzate, CNR, Milan, Italy.

PMID: 2032724
DOI: 10.1016/0888-7543(91)90424-d

Abstract

An EagI-EcoRI clone of human genomic DNA, p2-7, mapped to Xq24 has been sequenced. This analysis has confirmed the presence of a CpG island and has identified the first exon of the human LAMP2 gene, encoding a glycoprotein of the lysosomal membrane. Since the p2-7 clone corresponds to single-copy DNA, we can assign the human LAMP2 gene to Xq24.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Antigens, CD*
Base Sequence
Cloning, Molecular
DNA Probes
Dinucleoside Phosphates / genetics*
Exons
Humans
Lysosomal Membrane Proteins
Lysosomal-Associated Membrane Protein 2
Membrane Glycoproteins / genetics*
Methylation
Molecular Sequence Data
Repetitive Sequences, Nucleic Acid
X Chromosome*

Substances

Antigens, CD
DNA Probes
Dinucleoside Phosphates
LAMP2 protein, human
Lysosomal-Associated Membrane Protein 2
Lysosomal Membrane Proteins
Membrane Glycoproteins
cytidylyl-3'-5'-guanosine