Abstract
A new nucleotide antibiotic, phosmidosine was isolated from a culture filtrate of a newly isolated streptomycete identified as Streptomyces sp. RK-16. HRFAB-MS and elemental analysis established the molecular formula of C16H24N7O8P. 1H, 13C and 31P NMR indicated the presence of a methyl phosphate group and UV spectra were similar to those of 8-hydroxyadenosine. The antibiotic inhibited spore formation of Botrytis cinerea at the concentration of 0.25 micrograms/ml.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Chemical Phenomena
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Chemistry, Physical
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Chromatography, High Pressure Liquid
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Fermentation
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Magnetic Resonance Spectroscopy
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Mitosporic Fungi / drug effects
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Mitosporic Fungi / physiology
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Molecular Structure
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Purine Nucleotides / chemistry
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Purine Nucleotides / isolation & purification
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Purine Nucleotides / pharmacology
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Spectrometry, Mass, Fast Atom Bombardment
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Spores, Fungal / drug effects
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Streptomyces / metabolism
Substances
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Antifungal Agents
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Purine Nucleotides
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phosmidosine