How vital is sleep in Huntington's disease?

J Neurol. 2010 Jun;257(6):882-97. doi: 10.1007/s00415-010-5517-4. Epub 2010 Mar 24.

Abstract

Huntington's disease (HD) is a fatal neurodegenerative disease caused by an abnormal expansion of a CAG repeat in exon 1 of the HD gene on chromosome 4. The disease runs a debilitating and progressive course with an average survival of 15-25 years after disease onset. HD patients classically develop involuntary movements including chorea, as well as progressive cognitive and psychiatric disturbances, although a number of other features have also been reported, including changes in sleep and circadian rhythms; it is this latter area that forms the focus of this review.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / physiopathology
  • Humans
  • Huntington Disease / physiopathology*
  • Models, Neurological
  • Sleep / physiology*