Cognitive performance and mood in patients on the waiting list for liver transplantation and their relation to the model for end-stage liver disease

Arq Neuropsiquiatr. 2010 Feb;68(1):62-6. doi: 10.1590/s0004-282x2010000100014.

Abstract

Objective: To investigate the links between depression and cognitive functioning in patients with Hepatitis C and other chronic liver diseases with and without the use of alcohol on the waiting list for liver transplantation and their associations with the MELD classification.

Method: 40 patients were evaluated on a waiting list for liver transplant by a battery of neuropsychological tests, depression scales and interview at the Liver Transplant Service, of the Hospital das Clínicas University of São Paulo Medical School.

Results: After splitting the sample according to the education, the results showed statistical significance in the comparisons between groups of MELD > 15 and <15 in the following functions: estimated IQ, visual-spatial delayed recall and recognition as part of episodic memory and short term memory.

Conclusion: These findings, usually found in hepatic encephalopathy, corroborated with the literature and emphasized the need to investigate in more detail the cognitive functions of these patients in order to facilitate the adoption of different conducts.

MeSH terms

  • Affect*
  • Chronic Disease
  • Cognition Disorders / diagnosis
  • Cognition Disorders / etiology*
  • Cross-Sectional Studies
  • Depression / psychology*
  • Educational Status
  • Female
  • Hepatic Encephalopathy / diagnosis
  • Hepatic Encephalopathy / etiology*
  • Hepatic Encephalopathy / psychology
  • Humans
  • Liver Cirrhosis / complications*
  • Liver Cirrhosis / surgery
  • Liver Transplantation / psychology*
  • Male
  • Neuropsychological Tests
  • Patient Selection
  • Prospective Studies
  • Severity of Illness Index
  • Waiting Lists