Solitary fibrous tumor of soft tissue: a case report and immunohistochemical study

Med Mol Morphol. 2010 Mar;43(1):60-4. doi: 10.1007/s00795-009-0451-1. Epub 2010 Mar 26.

Abstract

A case of solitary fibrous tumor (SFT) arising in the soft tissue of the left inguinal region is reported. A 57-year-old Japanese woman presented with a nonadherent, well-defined, oval mass that was 2 x 3 cm in diameter and located in the inguinal soft tissue. Microscopic evaluation showed proliferation of spindle-shaped, fibroblast-like cells by the coexistence of hypo- and hypercellular areas with mast cell infiltration separated by hemangiopericytoma-like blood vessels. Immunohistochemistry revealed strong expression of CD34 and CD99 in the fibroblast-like cells, supporting the diagnosis of SFT. Although the patient was free of symptoms such as hypoglycemia, immunoreactive insulin-like growth factor (IGF)-II was localized in the socalled Golgi area of the spindle-shaped cells. In conclusion, immunoreactive IGF-II was detected in SFT that was not associated with hypoglycemia.

Publication types

  • Case Reports

MeSH terms

  • 12E7 Antigen
  • Abdominal Neoplasms / chemistry
  • Abdominal Neoplasms / diagnosis*
  • Abdominal Neoplasms / surgery
  • Antigens, CD / analysis
  • Antigens, CD34 / analysis
  • Cell Adhesion Molecules / analysis
  • Female
  • Golgi Apparatus / chemistry
  • Humans
  • Hypoglycemia / metabolism
  • Immunohistochemistry
  • Inguinal Canal*
  • Insulin-Like Growth Factor II / analysis
  • Middle Aged
  • Solitary Fibrous Tumors / chemistry
  • Solitary Fibrous Tumors / diagnosis*
  • Solitary Fibrous Tumors / surgery

Substances

  • 12E7 Antigen
  • Antigens, CD
  • Antigens, CD34
  • CD99 protein, human
  • Cell Adhesion Molecules
  • Insulin-Like Growth Factor II