Abstract
Pandemic 2009 H1N1 virus isolates containing the neuraminidase inhibitor resistance mutation H275Y have been reported. We describe rapid selection for the H275Y resistance mutation during therapy in 2 immunocompromised individuals at 9 and 14 days of therapy, as well as the first described case of clinically significant resistance to peramivir.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acids, Carbocyclic
-
Amino Acid Substitution / genetics
-
Antiviral Agents / pharmacology*
-
Cyclopentanes / pharmacology*
-
Drug Resistance, Viral*
-
Female
-
Guanidines / pharmacology*
-
Humans
-
Immunocompromised Host
-
Influenza A Virus, H1N1 Subtype / drug effects*
-
Influenza A Virus, H1N1 Subtype / genetics
-
Influenza A Virus, H1N1 Subtype / isolation & purification
-
Influenza, Human / drug therapy*
-
Influenza, Human / virology*
-
Male
-
Middle Aged
-
Molecular Sequence Data
-
Mutation, Missense
-
Oseltamivir / pharmacology*
-
RNA, Viral / genetics
-
Selection, Genetic
-
Sequence Analysis, DNA
-
Young Adult
Substances
-
Acids, Carbocyclic
-
Antiviral Agents
-
Cyclopentanes
-
Guanidines
-
RNA, Viral
-
Oseltamivir
-
peramivir
Associated data
-
GENBANK/GU571152
-
GENBANK/GU571153
-
GENBANK/GU571154
-
GENBANK/GU571155
-
GENBANK/GU571156