Overrecruitment in the aging brain as a function of task demands: evidence for a compensatory view

J Cogn Neurosci. 2011 Apr;23(4):801-15. doi: 10.1162/jocn.2010.21490. Epub 2010 Mar 29.

Abstract

This study used fMRI to investigate the neural effects of increasing cognitive demands in normal aging and their role for performance. Simple and complex go/no-go tasks were used with two versus eight colored letters as go stimuli, respectively. In both tasks, no-go stimuli could produce high conflict (same letter, different color) or low conflict (colored numbers) with go stimuli. Multivariate partial least square analysis of fMRI data showed that older adults overengaged a cohesive pattern of fronto-parietal regions with no-go stimuli under the specific combination of factors which progressively amplified task demands: high conflict no-go trials in the first phase of the complex task. This early neural overrecruitment was positively correlated with a lower error rate in the older group. Thus, the present data suggest that age-related extra-recruitment of neural resources can be beneficial for performance under taxing task conditions, such as when novel, weak, and complex rules have to be acquired.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Psychological / physiology*
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging*
  • Analysis of Variance
  • Brain / blood supply
  • Brain / physiology*
  • Brain Mapping*
  • Color Perception
  • Conflict, Psychological*
  • Decision Making
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Oxygen / blood
  • Photic Stimulation / methods
  • Reaction Time
  • Young Adult

Substances

  • Oxygen