New automated hepatitis C virus (HCV) core antigen assay as an alternative to real-time PCR for HCV RNA quantification

J Clin Microbiol. 2010 Jun;48(6):2253-6. doi: 10.1128/JCM.01856-09. Epub 2010 Mar 29.

Abstract

An automated hepatitis C virus (HCV) antigen (Ag) assay was evaluated with clinical samples. Determination of HCV Ag and RNA levels in 282 subjects using Abbott HCV Ag and Roche Cobas TaqMan assays revealed that these two tests were highly correlated (r = 0.9464). Thus, the HCV Ag assay could be an alternative test to quantitative reverse transcription-PCR.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Antigens, Viral / blood*
  • Automation / methods*
  • Hepacivirus / isolation & purification*
  • Humans
  • RNA, Viral / blood
  • Reverse Transcriptase Polymerase Chain Reaction
  • Statistics as Topic
  • Viral Core Proteins / blood*
  • Viral Load / methods*

Substances

  • Antigens, Viral
  • RNA, Viral
  • Viral Core Proteins
  • nucleocapsid protein, Hepatitis C virus