Blue rubber bleb nevus syndrome with late onset of central nervous system symptomatic involvement

Giampaolo Tomelleri; Manuel Cappellari; Alessandro Di Matteo; Tiziano Zanoni; Chiara Colato; Paolo Bovi; Giuseppe Moretto

doi:10.1007/s10072-010-0250-4

Blue rubber bleb nevus syndrome with late onset of central nervous system symptomatic involvement

Neurol Sci. 2010 Aug;31(4):501-4. doi: 10.1007/s10072-010-0250-4. Epub 2010 Mar 30.

Authors

Giampaolo Tomelleri¹, Manuel Cappellari, Alessandro Di Matteo, Tiziano Zanoni, Chiara Colato, Paolo Bovi, Giuseppe Moretto

Affiliation

¹ Unità Operativa Di Neurologia, Azienda Ospedaliera-Universitaria, Verona, Italy. [email protected]

PMID: 20352269
DOI: 10.1007/s10072-010-0250-4

Abstract

Blue rubber bleb nevus syndrome is a rare vascular disorder characterized by cavernous angiomas of skin and other organs including the gastrointestinal tract. The central nervous system involvement is seldom reported, and neurological symptoms at onset in adulthood are extremely rare. Here, we describe a case of 82-year-old patient presenting multiple skin haemangiomas for some years, who was admitted for a brain hemorrhage. The MRI demonstrated the presence of multiple cavernous angiomas within the cerebral tissue.

Publication types

Case Reports

MeSH terms

Aged, 80 and over
Central Nervous System Diseases / etiology*
Central Nervous System Diseases / pathology*
Fatal Outcome
Hemangioma, Cavernous, Central Nervous System / complications*
Hemangioma, Cavernous, Central Nervous System / pathology*
Humans
Intracranial Arteriovenous Malformations / complications
Intracranial Arteriovenous Malformations / pathology
Magnetic Resonance Imaging
Male
Nevus, Blue / complications*
Nevus, Blue / pathology*
Skin / pathology
Stroke / complications
Tomography, X-Ray Computed