Radiotherapy: Neurocognitive considerations in the treatment of brain metastases

Nicholas F Marko; Robert J Weil

doi:10.1038/nrclinonc.2010.30

Radiotherapy: Neurocognitive considerations in the treatment of brain metastases

Nat Rev Clin Oncol. 2010 Apr;7(4):185-6. doi: 10.1038/nrclinonc.2010.30.

Authors

Nicholas F Marko¹, Robert J Weil

Affiliation

¹ Department of Neurosurgery, The Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, ND-40, 9500 Euclid Avenue, Cleveland, OH 44195, USA. [email protected]

PMID: 20354539
DOI: 10.1038/nrclinonc.2010.30

Abstract

The results of a randomized, controlled trial investigating the neurocognitive effects of stereotactic radiosurgery (SRS), with or without whole-brain radiation therapy (WBRT), to treat brain metastases demonstrated a significant reduction in learning and memory, associated with the addition of WBRT to SRS. the results indicate that SRS monotherapy is an effective and safe initial management strategy for brain metastases.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Brain Neoplasms / mortality
Brain Neoplasms / radiotherapy*
Brain Neoplasms / surgery
Cognition Disorders*
Disease Progression
Humans
Karnofsky Performance Status
Learning
Learning Disabilities
Memory
Memory Disorders
Quality of Life
Radiosurgery*
Radiotherapy*
Treatment Outcome