D225G mutation in the hemagglutinin protein found in 3 severe cases of 2009 pandemic influenza A (H1N1) in Spain

Andrés Antón; María Angeles Marcos; Miguel Julián Martínez; Susana Ramón; Anna Martínez; Neus Cardeñosa; Pere Godoy; Nuria Torner; Patricia De Molina; Ricard Isanta; María Teresa Jiménez de Anta; Tomàs Pumarola

doi:10.1016/j.diagmicrobio.2010.02.002

D225G mutation in the hemagglutinin protein found in 3 severe cases of 2009 pandemic influenza A (H1N1) in Spain

Diagn Microbiol Infect Dis. 2010 Jun;67(2):207-8. doi: 10.1016/j.diagmicrobio.2010.02.002. Epub 2010 Mar 31.

Authors

Andrés Antón¹, María Angeles Marcos, Miguel Julián Martínez, Susana Ramón, Anna Martínez, Neus Cardeñosa, Pere Godoy, Nuria Torner, Patricia De Molina, Ricard Isanta, María Teresa Jiménez de Anta, Tomàs Pumarola

Affiliation

¹ Microbiology Laboratory, Hospital Clínic, 08036 Barcelona, Spain. [email protected]

PMID: 20356695
DOI: 10.1016/j.diagmicrobio.2010.02.002

Abstract

From 27 April to 16 December 2009, we analyzed the hemagglutinin gene sequence of 2009 pandemic influenza A (H1N1) virus in 189 respiratory specimens. We only found the D225G mutation in 3 severe cases. However, it was not found in samples from other cases with or without clinical criteria of severity. The biologic significance of this mutation remains still unclear.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hemagglutinins, Viral / genetics*
Hemagglutinins, Viral / isolation & purification
Humans
Influenza A Virus, H1N1 Subtype / genetics*
Influenza A Virus, H1N1 Subtype / isolation & purification
Influenza, Human / virology*
Mutation, Missense*
Point Mutation*
Sequence Analysis, DNA
Spain

Substances

Hemagglutinins, Viral
hemagglutinin fusogenic peptide, influenza virus