Six patients with non-Hodgkin malignant lymphoma (NHL) in a series of 151 cases showed partial deletion of chromosome 2 when studied cytogenetically. Three had deletions of bands 2p14-p22 and three others had a deletion of bands 2q22-q24 in common. The deletions were associated with other abnormalities in each case and were not associated with a particular subtype of NHL. These deletions are secondary, apparently nonrandom, new abnormalities associated with NHL.