Background: Soft tissue liposarcomas are quite common in the adult population, whereas liposarcoma of the larynx is exceedingly rare.
Methods: We describe an exceptional case of liposarcoma of the posterior aspect of the left arytenoid in a 62-year-old woman who was treated with two endoscopic excisions and adjuvant radiotherapy (RT). This is the 32nd case of laryngeal liposarcoma reported in the English literature.
Results: After a 20 months follow-up, no local, regional recurrences or distant metastases were detected, and no functional complications are described for the patient.
Conclusion: This case report highlights that endoscopic surgical treatment enables excellent organ and functional preservation. However, recurrence of laryngeal liposarcoma is the principal risk, so extended follow-up is essential. RT has no defined role in treatment but can be discussed, especially considering the surgical margins and recurrence status.