Abstract
In a male patient with rhinocerebral invasive aspergillosis, prolonged high-dosage oral administration of voriconazole led to hepatotoxicity combined with a severe cutaneous reaction while intravenous administration in the same patient did not. High concentrations in the portal blood precipitate liver enzyme abnormalities, and therefore, oral administration of voriconazole may have a hepatotoxicity profile different from that of intravenous (i.v.) administration. Intravenously administered voriconazole might still be an option after oral-voriconazole-induced toxicity has resolved.
MeSH terms
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Administration, Oral
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Antifungal Agents / administration & dosage*
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Antifungal Agents / adverse effects*
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Antifungal Agents / blood
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Drug Eruptions / etiology
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Drug Eruptions / pathology
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Humans
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Injections, Intravenous
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Liver / drug effects
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Liver / enzymology
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Liver / injuries
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Male
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Middle Aged
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Neuroaspergillosis / blood
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Neuroaspergillosis / drug therapy*
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Neuroaspergillosis / enzymology
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Pyrimidines / administration & dosage*
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Pyrimidines / adverse effects*
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Pyrimidines / blood
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Sphenoid Sinusitis / drug therapy*
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Triazoles / administration & dosage*
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Triazoles / adverse effects*
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Triazoles / blood
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Voriconazole
Substances
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Antifungal Agents
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Pyrimidines
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Triazoles
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Voriconazole