Annulated diketopiperazines from dipeptides or Schöllkopf reagents via tandem cyclization-intramolecular N-arylation

Org Lett. 2010 May 7;12(9):2162-5. doi: 10.1021/ol100663y.

Abstract

Facile CuI-mediated N-arylation of diketopiperazine using the Fukuyama modification of the Ullmann-Goldberg reaction can be exploited in new approaches to enantiopure polycyclic diketopiperazines from easily assembled dipeptides or functionalized Schöllkopf reagents.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Cyclization
  • Diketopiperazines / chemistry*
  • Dipeptides / chemistry*
  • Indicators and Reagents / chemistry*
  • Models, Molecular

Substances

  • Diketopiperazines
  • Dipeptides
  • Indicators and Reagents