Abstract
Gitelman syndrome is a rare inherited tubulopathy, characterized by hypomagnesemia, hypokalemia, metabolic alkalosis, hypocalciuria and hyperreninemic hyperaldosteronism. The clinical spectrum is wide and includes: cramps, myalgias, muscle weakness, until episodes of carpo-podalic spasm, tetania, rhabdomyolysis and paralysis. Some cases have been described in literature underlining the association of this condition with chondrocalcinosis, as a typical example of hypomagnesemia-induced crystal deposition disease. The therapy of Gitelman syndrome consists on the administration of defective electrolytes, although not always effective. We describe two cases of Gitelman syndrome associated with chondrocalcinosis showing the wide range of presentation of this clinical condition.
Publication types
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Case Reports
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Comparative Study
MeSH terms
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Acetaminophen / administration & dosage
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Acetaminophen / therapeutic use
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Adult
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Analgesics, Non-Narcotic / administration & dosage
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Analgesics, Non-Narcotic / therapeutic use
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / therapeutic use
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Chondrocalcinosis / complications*
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Chondrocalcinosis / diagnosis
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Chondrocalcinosis / diagnostic imaging
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Chondrocalcinosis / drug therapy
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Female
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Gitelman Syndrome / complications*
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Gitelman Syndrome / diagnosis
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Gitelman Syndrome / drug therapy
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Glucocorticoids / administration & dosage
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Glucocorticoids / therapeutic use
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Humans
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Hypokalemia / etiology
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Knee Joint / diagnostic imaging
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Magnesium / blood
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Methylprednisolone / administration & dosage
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Methylprednisolone / therapeutic use
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Middle Aged
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Radiography
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Ultrasonography
Substances
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Analgesics, Non-Narcotic
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Glucocorticoids
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Acetaminophen
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Magnesium
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Methylprednisolone