Malignant osteopetrosis: hypercalcaemia after bone marrow transplantation

Arch Dis Child. 1991 May;66(5):638-9. doi: 10.1136/adc.66.5.638.

Abstract

A 3 year old girl presented with malignant osteopetrosis, which was treated by allogeneic bone marrow transplantation. Successful engraftment was complicated by prolonged hypercalcaemia, which was controlled by a combination of a bisphosphonate, phosphate infusions, vigorous resalination, and salmon calcitonin. She was alive and well 16 months after the transplant.

Publication types

  • Case Reports

MeSH terms

  • Bone Marrow Transplantation*
  • Calcitonin / therapeutic use
  • Child, Preschool
  • Diphosphonates / therapeutic use
  • Female
  • Humans
  • Hypercalcemia / drug therapy
  • Hypercalcemia / etiology*
  • Osteopetrosis / surgery*
  • Pamidronate
  • Phosphates / therapeutic use
  • Postoperative Complications / etiology*

Substances

  • Diphosphonates
  • Phosphates
  • salmon calcitonin
  • Calcitonin
  • Pamidronate