Imaging breast cancer chemotherapy response with light. Commentary on Soliman et al., p. 2605

Clin Cancer Res. 2010 May 1;16(9):2486-8. doi: 10.1158/1078-0432.CCR-10-0397. Epub 2010 Apr 20.

Abstract

Diffuse optical spectroscopy (DOS), which is used to image tumor metabolic response to neoadjuvant chemotherapy (NAC), shows large changes in tumor functional parameters with significant reductions in oxy- and deoxyhemoglobin for responders versus nonresponders. Although investigational, DOS may provide a cost-effective, risk-free method for optimizing NAC drug and dosing strategies for individual patients.

Publication types

  • Comment

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology
  • Chemotherapy, Adjuvant
  • Diagnostic Imaging / methods*
  • Female
  • Hemoglobins / metabolism
  • Humans
  • Middle Aged
  • Neoadjuvant Therapy
  • Oxyhemoglobins / metabolism
  • Prognosis
  • Reproducibility of Results
  • Time Factors
  • Treatment Outcome

Substances

  • Hemoglobins
  • Oxyhemoglobins
  • deoxyhemoglobin